Assembly mechanism of the inflammasome sensor AIM2 revealed by single molecule analysis

Pathogenic dsDNA prompts AIM2 assembly leading to the formation of the inflammasome, a multimeric complex that triggers the inflammatory response. The recognition of foreign dsDNA involves AIM2 self-assembly concomitant with dsDNA binding. However, we lack mechanistic and kinetic information on the...

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Detalles Bibliográficos
Autores principales: Sharma, Meenakshi, de Alba, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693601/
https://www.ncbi.nlm.nih.gov/pubmed/38042863
http://dx.doi.org/10.1038/s41467-023-43691-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693601/
https://www.ncbi.nlm.nih.gov/pubmed/38042863
http://dx.doi.org/10.1038/s41467-023-43691-4

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