Cargando…
Assembly mechanism of the inflammasome sensor AIM2 revealed by single molecule analysis
Pathogenic dsDNA prompts AIM2 assembly leading to the formation of the inflammasome, a multimeric complex that triggers the inflammatory response. The recognition of foreign dsDNA involves AIM2 self-assembly concomitant with dsDNA binding. However, we lack mechanistic and kinetic information on the...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693601/ https://www.ncbi.nlm.nih.gov/pubmed/38042863 http://dx.doi.org/10.1038/s41467-023-43691-4 |