Clonal heterogeneity in ER+ breast cancer reveals the proteasome and PKC as potential therapeutic targets

Intratumoral heterogeneity impacts the success or failure of anti-cancer therapies. Here, we investigated the evolution and mechanistic heterogeneity in clonal populations of cell models for estrogen receptor positive breast cancer. To this end, we established barcoded models of luminal breast cance...

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Detalles Bibliográficos
Autores principales: Beumers, Lukas, Vlachavas, Efstathios-Iason, Borgoni, Simone, Schwarzmüller, Luisa, Penso-Dolfin, Luca, Michels, Birgitta E., Sofyali, Emre, Burmester, Sara, Heiss, Daniela, Wilhelm, Heike, Yarden, Yosef, Helm, Dominic, Will, Rainer, Goncalves, Angela, Wiemann, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693625/
https://www.ncbi.nlm.nih.gov/pubmed/38042915
http://dx.doi.org/10.1038/s41523-023-00604-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693625/
https://www.ncbi.nlm.nih.gov/pubmed/38042915
http://dx.doi.org/10.1038/s41523-023-00604-4

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