In vitro and in vivo modelling of mutant JAK3/STAT5 signaling in leukemia

Mutations within the IL7-R-JAK-STAT signaling pathway are important drivers of T-cell acute lymphoblastic leukemia (T-ALL). Here we describe the important steps required to generate retroviral particles for the stable expression of mutant JAK3 constructs that induce constitutive JAK/STAT signaling....

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Detalles Bibliográficos
Autores principales: Omari, Sofia A., Kosasih, Hansen J., Chung, Thomas, de Bock, Charles E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694137/
http://dx.doi.org/10.1016/j.heliyon.2023.e22085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694137/
http://dx.doi.org/10.1016/j.heliyon.2023.e22085

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