Overall avidity declines in TCR repertoires during latent CMV but not EBV infection

INTRODUCTION: The avidity of the T-cell receptor (TCR) for antigenic peptides presented by the MHC (pMHC) on cells is an essential parameter for efficient T cell-mediated immunity. Yet, whether the TCR-ligand avidity can drive the clonal evolution of virus antigen-specific CD8 T cells, and how this...

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Detalles Bibliográficos
Autores principales: Couturaud, Barbara, Doix, Bastien, Carretero-Iglesia, Laura, Allard, Mathilde, Pradervand, Sylvain, Hebeisen, Michael, Rufer, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694213/
http://dx.doi.org/10.3389/fimmu.2023.1293090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694213/
http://dx.doi.org/10.3389/fimmu.2023.1293090

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