Exploring potent aldose reductase inhibitors for anti-diabetic (anti-hyperglycemic) therapy: integrating structure-based drug design, and MMGBSA approaches

Aldose reductase (AR) is an important target in the development of therapeutics against hyper-glycemia-induced health complications such as retinopathy, etc. In this study, we employed a combination of structure-based drug design, molecular simulation, and free energy calculation approaches to ident...

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Detalles Bibliográficos
Autores principales: Shahab, Muhammad, Zheng, Guojun, Alshabrmi, Fahad M., Bourhia, Mohammed, Wondmie, Gezahign Fentahun, Mohammad Salamatullah, Ahmad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694256/
http://dx.doi.org/10.3389/fmolb.2023.1271569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694256/
http://dx.doi.org/10.3389/fmolb.2023.1271569

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