An activity-based functional test for identifying homologous recombination deficiencies across cancer types in real time

Homologous recombination (HR)-mediated DNA repair is a prerequisite for maintaining genome stability. Cancer cells displaying HR deficiency (HRD) are selectively eliminated by poly(ADP-ribose) polymerase inhibitors (PARPis). To date, sequencing of HR-associated genes and analyzing genome instability...

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Detalles Bibliográficos
Autores principales: Lee, Chih-Ying, Cheng, Wen-Fang, Lin, Po-Han, Chen, Yu-Li, Huang, Shih-Han, Lei, Kai-Hang, Chang, Ko-Yu, Ko, Min-Yu, Chi, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694588/
https://www.ncbi.nlm.nih.gov/pubmed/37863059
http://dx.doi.org/10.1016/j.xcrm.2023.101247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694588/
https://www.ncbi.nlm.nih.gov/pubmed/37863059
http://dx.doi.org/10.1016/j.xcrm.2023.101247

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