An siRNA library screen identifies CYLD and USP34 as deubiquitinases that regulate GPCR-p38 MAPK signaling and distinct inflammatory responses

G protein–coupled receptors (GPCRs) are highly druggable and implicated in numerous diseases, including vascular inflammation. GPCR signals are transduced from the plasma membrane as well as from endosomes and controlled by posttranslational modifications. The thrombin-activated GPCR protease-activa...

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Detalles Bibliográficos
Autores principales: Cheng, Norton, Trejo, JoAnn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694601/
https://www.ncbi.nlm.nih.gov/pubmed/37865315
http://dx.doi.org/10.1016/j.jbc.2023.105370

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694601/
https://www.ncbi.nlm.nih.gov/pubmed/37865315
http://dx.doi.org/10.1016/j.jbc.2023.105370

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