Redirecting the specificity of tripartite motif containing-21 scaffolds using a novel discovery and design approach

Hijacking the ubiquitin proteasome system to elicit targeted protein degradation (TPD) has emerged as a promising therapeutic strategy to target and destroy intracellular proteins at the post-translational level. Small molecule–based TPD approaches, such as proteolysis-targeting chimeras (PROTACs) a...

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Detalles Bibliográficos
Autores principales: VanDyke, Derek, Xu, Linda, Sargunas, Paul R., Gilbreth, Ryan N., Baca, Manuel, Gao, Changshou, Hunt, James, Spangler, Jamie B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694607/
https://www.ncbi.nlm.nih.gov/pubmed/37866632
http://dx.doi.org/10.1016/j.jbc.2023.105381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694607/
https://www.ncbi.nlm.nih.gov/pubmed/37866632
http://dx.doi.org/10.1016/j.jbc.2023.105381

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