High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma

Uveal melanoma (UM) is the most prevalent cancer of the eye in adults, driven by activating mutation of GNAQ/GNA11; however, there are limited therapies against UM and metastatic UM (mUM). Here, we perform a high-throughput chemogenetic drug screen in GNAQ-mutant UM contrasted with BRAF-mutant cutan...

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Detalles Bibliográficos
Autores principales: Arang, Nadia, Lubrano, Simone, Ceribelli, Michele, Rigiracciolo, Damiano C., Saddawi-Konefka, Robert, Faraji, Farhoud, Ramirez, Sydney I., Kim, Daehwan, Tosto, Frances A., Stevenson, Erica, Zhou, Yuan, Wang, Zhiyong, Bogomolovas, Julius, Molinolo, Alfredo A., Swaney, Danielle L., Krogan, Nevan J., Yang, Jing, Coma, Silvia, Pachter, Jonathan A., Aplin, Andrew E., Alessi, Dario R., Thomas, Craig J., Gutkind, J. Silvio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694608/
https://www.ncbi.nlm.nih.gov/pubmed/37858338
http://dx.doi.org/10.1016/j.xcrm.2023.101244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694608/
https://www.ncbi.nlm.nih.gov/pubmed/37858338
http://dx.doi.org/10.1016/j.xcrm.2023.101244

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