Aurora A kinase inhibition induces accumulation of SCLC tumor cells in mitosis with restored interferon signaling to increase response to PD-L1

Despite small cell lung cancers (SCLCs) having a high mutational burden, programmed death-ligand 1 (PD-L1) immunotherapy only modestly increases survival. A subset of SCLCs that lose their ASCL1 neuroendocrine phenotype and restore innate immune signaling (termed the “inflammatory” subtype) have dur...

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Detalles Bibliográficos
Autores principales: Li, Yixiang, Mahadevan, Navin R., Duplaquet, Leslie, Hong, Deli, Durmaz, Yavuz T., Jones, Kristen L., Cho, Hyeonseo, Morrow, Murry, Protti, Andrea, Poitras, Michael J., Springer, Benjamin F., Bronson, Roderick T., Gong, Xueqian, Hui, Yu-Hua, Du, Jian, Southard, Jackson, Thai, Tran, Li, Shuqiang, Lizotte, Patrick H., Gokhale, Prafulla C., Nguyen, Quang-De, Oser, Matthew G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694667/
https://www.ncbi.nlm.nih.gov/pubmed/37992688
http://dx.doi.org/10.1016/j.xcrm.2023.101282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694667/
https://www.ncbi.nlm.nih.gov/pubmed/37992688
http://dx.doi.org/10.1016/j.xcrm.2023.101282

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