HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, which lacks effective therapies. Here, we demonstrate that the transcription factor, homeobox C6 (HOXC6), is overexpressed in most PDACs, and its inhibition blocks PDAC tumor growth and metastasis. HOXC6 transcriptionally activ...

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Detalles Bibliográficos
Autores principales: Malvi, Parmanand, Chava, Suresh, Cai, Guoping, Hu, Kai, Zhu, Lihua Julie, Edwards, Yvonne J.K., Green, Michael R., Gupta, Romi, Wajapeyee, Narendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694669/
https://www.ncbi.nlm.nih.gov/pubmed/37951219
http://dx.doi.org/10.1016/j.xcrm.2023.101285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694669/
https://www.ncbi.nlm.nih.gov/pubmed/37951219
http://dx.doi.org/10.1016/j.xcrm.2023.101285

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