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Immune imprinting as a barrier to effective COVID-19 vaccines

Wang and colleagues show that immune imprinting impairs neutralizing antibody titers for bivalent mRNA vaccination against SARS-CoV-2 Omicron subvariants. Imprinting from three doses of monovalent vaccine can be alleviated by BA.5 or BQ-lineage breakthrough infection but not by a bivalent booster.(1...

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Detalles Bibliográficos
Autores principales: Faraone, Julia N., Liu, Shan-Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694758/
https://www.ncbi.nlm.nih.gov/pubmed/37992689
http://dx.doi.org/10.1016/j.xcrm.2023.101291