Design and selection of anti-PD-L1 single-domain antibody and tumor necrosis factor superfamily ligands for an optimal vectorization in an oncolytic virus

Arming oncolytic viruses with transgenes encoding immunomodulators improves their therapeutic efficacy by enhancing and/or sustaining the innate and adaptive anti-tumoral immune responses. We report here the isolation, selection, and vectorization of a blocking anti-human PDL1 single-domain antibody...

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Detalles Bibliográficos
Autores principales: Remy, Christelle, Pintado, Elodie, Dunlop, Marshall, Schön, Shirley, Kleinpeter, Patricia, Rozanes, Homa, Fend, Laetitia, Brandely, Renée, Geist, Michel, Suhner, Delphine, Winter, Eline, Silvestre, Nathalie, Huguet, Claire, Fitzgerald, Peter, Quéméneur, Eric, Marchand, Jean-Baptiste
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694795/
http://dx.doi.org/10.3389/fbioe.2023.1247802

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694795/
http://dx.doi.org/10.3389/fbioe.2023.1247802

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