Five and six membered heterocyclic rings endowed with azobenzene as dual EGFR(T790M) and VEGFR-2 inhibitors: design, synthesis, in silico ADMET profile, molecular docking, dynamic simulation and anticancer evaluations

Novel azobenzene scaffold-joined heterocyclic isoxazole, pyrazole, triazole, and/or triazine moieties have been developed and synthesized utilizing microwave and traditional methods. Our compounds were tested for growth inhibition of A549, MCF-7, HCT-116, and HepG2 tumors by dual targeting the VEGFR...

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Detalles Bibliográficos
Autores principales: Anwer, Kurls E., El-Hddad, Sanadelaslam S. A., Abd El-Sattar, Nour E. A., El-morsy, Ahmed, Khedr, Fathalla, Mohamady, Samy, Keshek, Doaa E., Salama, Samir A., El-Adl, Khaled, Hanafy, Noura S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695193/
http://dx.doi.org/10.1039/d3ra06614b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695193/
http://dx.doi.org/10.1039/d3ra06614b

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