The miR-221/222 cluster regulates hematopoietic stem cell quiescence and multipotency by suppressing both Fos/AP-1/IEG pathway activation and stress-like differentiation to granulocytes

Throughout life, hematopoietic stem cells (HSCs), residing in bone marrow (BM), continuously regenerate erythroid/megakaryocytic, myeloid, and lymphoid cell lineages. This steady-state hematopoiesis from HSC and multipotent progenitors (MPPs) in BM can be perturbed by stress. The molecular controls...

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Detalles Bibliográficos
Autores principales: Jani, Peter K., Petkau, Georg, Kawano, Yohei, Klemm, Uwe, Guerra, Gabriela Maria, Heinz, Gitta Anne, Heinrich, Frederik, Durek, Pawel, Mashreghi, Mir-Farzin, Melchers, Fritz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695376/
https://www.ncbi.nlm.nih.gov/pubmed/37983263
http://dx.doi.org/10.1371/journal.pbio.3002015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695376/
https://www.ncbi.nlm.nih.gov/pubmed/37983263
http://dx.doi.org/10.1371/journal.pbio.3002015

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