Avoiding false discoveries in single-cell RNA-seq by revisiting the first Alzheimer’s disease dataset

Mathys et al. conducted the first single-nucleus RNA-seq (snRNA-seq) study of Alzheimer’s disease (AD) (Mathys et al., 2019). With bulk RNA-seq, changes in gene expression across cell types can be lost, potentially masking the differentially expressed genes (DEGs) across different cell types. Throug...

Descripción completa

Detalles Bibliográficos
Autores principales: Murphy, Alan E, Fancy, Nurun, Skene, Nathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695556/
https://www.ncbi.nlm.nih.gov/pubmed/38047913
http://dx.doi.org/10.7554/eLife.90214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695556/
https://www.ncbi.nlm.nih.gov/pubmed/38047913
http://dx.doi.org/10.7554/eLife.90214

Ejemplares similares