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Avoiding false discoveries in single-cell RNA-seq by revisiting the first Alzheimer’s disease dataset

Mathys et al. conducted the first single-nucleus RNA-seq (snRNA-seq) study of Alzheimer’s disease (AD) (Mathys et al., 2019). With bulk RNA-seq, changes in gene expression across cell types can be lost, potentially masking the differentially expressed genes (DEGs) across different cell types. Throug...

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Detalles Bibliográficos
Autores principales:	Murphy, Alan E, Fancy, Nurun, Skene, Nathan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Chromosomes and Gene Expression
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695556/ https://www.ncbi.nlm.nih.gov/pubmed/38047913 http://dx.doi.org/10.7554/eLife.90214

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