Cargando…

Crystal Modifications of a Cyclic Guanosine Phosphorothioate Analogue, a Drug Candidate for Retinal Neurodegenerations

In contribution to the pharmaceutical development of cyclic guanosine monophosphorothioate analogue cGMPSA as a potential active pharmaceutical ingredient (API) for the treatment of inherited retinal degenerations (IRDs), its neutral form (cGMPSA‐H) and salts of sodium (‐Na), calcium (‐Ca), ammonium...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pérez, Oswaldo, Schipper, Nicolaas, Leandri, Valentina, Svensson, Per H., Bohlin, Martin, Loftsson, Thorsteinn, Bollmark, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695737/ https://www.ncbi.nlm.nih.gov/pubmed/37877436 http://dx.doi.org/10.1002/open.202300141

Ejemplares similares

Preparative Synthesis of an R(P)-Guanosine-3′,5′-Cyclic Phosphorothioate Analogue, a Drug Candidate for the Treatment of Retinal Degenerations
por: Pérez, Oswaldo, et al.
Publicado: (2021)

Structural Characterization Study of a Lipid Nanocapsule Formulation Intended for Drug Delivery Applications Using Small-Angle Scattering Techniques
por: Urimi, Dileep, et al.
Publicado: (2022)

Structural investigation into physiological DNA phosphorothioate modification
por: Lan, Wenxian, et al.
Publicado: (2016)

DNA Phosphorothioate Modifications Are Widely Distributed in the Human Microbiome
por: Sun, Yihua, et al.
Publicado: (2020)

Aqueous Prostaglandin Eye Drop Formulations
por: Jansook, Phatsawee, et al.
Publicado: (2022)

Monovalent selectivity of the cyclic guanosine monophosphate-activated ion channel
Publicado: (1990)

Regulation of Biofilm Exopolysaccharide Production by Cyclic Di-Guanosine Monophosphate
por: Poulin, Myles B., et al.
Publicado: (2021)

Regulation of DNA phosphorothioate modification in Salmonella enterica by DndB
por: He, Wei, et al.
Publicado: (2015)

Interactions of Dnd proteins involved in bacterial DNA phosphorothioate modification
por: Xiong, Wei, et al.
Publicado: (2015)

Oxidation of phosphorothioate DNA modifications leads to lethal genomic instability
por: Kellner, Stefanie, et al.
Publicado: (2017)

Phosphonylated Acyclic Guanosine Analogues with the 1,2,3-Triazole Linker
por: Głowacka, Iwona E., et al.
Publicado: (2015)

Optogenetic manipulation of cyclic guanosine monophosphate to probe phosphodiesterase activities in megakaryocytes
por: Zhang, Yujing, et al.
Publicado: (2022)

In Vivo Mutational Characterization of DndE Involved in DNA Phosphorothioate Modification
por: Lai, Chongde, et al.
Publicado: (2014)

Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators
por: Flierl, Ulrike, et al.
Publicado: (2015)

Nanopore Sequencing for Detection and Characterization of Phosphorothioate Modifications in Native DNA Sequences
por: Wadley, Taylor, et al.
Publicado: (2022)

Inhibition of PDE5A1 guanosine cyclic monophosphate (cGMP) hydrolysing activity by sildenafil analogues that inhibit cellular cGMP efflux
por: Subbotina, Anna, et al.
Publicado: (2017)

Guanosine 3',5'-cyclic monophosphate and the in vitro physiology of frog photoreceptor membranes
Publicado: (1977)

Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA
por: Ying, Wendy, et al.
Publicado: (2019)

Anomalous Properties of Cyclodextrins and Their Complexes in Aqueous Solutions
por: Loftsson, Thorsteinn, et al.
Publicado: (2023)

Contiguous Four‐guanosine Sequence in c‐myc Antisense Phosphorothioate Oligonucleotides Inhibits Cell Growth on Human Lung Cancer Cells: Possible Involvement of Cell Adhesion Inhibition
por: Saijo, Yasuo, et al.
Publicado: (1997)

DNA Phosphorothioate Modification Plays a Role in Peroxides Resistance in Streptomyces lividans
por: Dai, Daofeng, et al.
Publicado: (2016)

DNA phosphorothioate modification—a new multi-functional epigenetic system in bacteria
por: Wang, Lianrong, et al.
Publicado: (2018)

Quantitative mapping of DNA phosphorothioatome reveals phosphorothioate heterogeneity of low modification frequency
por: Li, Jinli, et al.
Publicado: (2019)

The DNA Phosphorothioation Restriction-Modification System Influences the Antimicrobial Resistance of Pathogenic Bacteria
por: Xu, Congrui, et al.
Publicado: (2023)

In Search of Enzymes with a Role in 3′, 5′-Cyclic Guanosine Monophosphate Metabolism in Plants
por: Gross, Inonge, et al.
Publicado: (2016)

Treatment of Cardiovascular Dysfunction with PDE3-Inhibitors in Moderate and Severe Hypothermia—Effects on Cellular Elimination of Cyclic Adenosine Monophosphate and Cyclic Guanosine Monophosphate
por: Kuzmiszyn, Adrina Kalasho, et al.
Publicado: (2022)

Solubility of Cyclodextrins and Drug/Cyclodextrin Complexes
por: Saokham, Phennapha, et al.
Publicado: (2018)

2-Hydroxypropyl-β-Cyclodextrin Aggregates: Identification and Development of Analytical Techniques
por: Sá Couto, André Rodrigues, et al.
Publicado: (2018)

Nepafenac-Loaded Cyclodextrin/Polymer Nanoaggregates: A New Approach to Eye Drop Formulation
por: Lorenzo-Veiga, Blanca, et al.
Publicado: (2019)

Characterization and Evaluation of Ternary Complexes of Ascorbic Acid with γ-Cyclodextrin and Poly(vinyl Alcohol)
por: Saokham, Phennapha, et al.
Publicado: (2020)

Regulation of Ca2+ current in frog ventricular cardiomyocytes by guanosine 5'-triphosphate analogues and isoproterenol
Publicado: (1993)

Phosphorothioate DNA as an antioxidant in bacteria
por: Xie, Xinqiang, et al.
Publicado: (2012)

In vitro analysis of phosphorothioate modification of DNA reveals substrate recognition by a multiprotein complex
por: Cao, Bo, et al.
Publicado: (2015)

An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides
por: Baker, Ysobel R., et al.
Publicado: (2022)

Increased Adhesion and Aggregation of Platelets Lacking Cyclic Guanosine 3′,5′-Monophosphate Kinase I
por: Massberg, Steffen, et al.
Publicado: (1999)

Influence of calcium on guanosine 3',5'-cyclic monophosphate levels in frog rod outer segments
Publicado: (1981)

Cell Surface Protein Disulfide Isomerase Regulates Natriuretic Peptide Generation of Cyclic Guanosine Monophosphate
por: Pan, Shuchong, et al.
Publicado: (2014)

Involvement of Cyclic Guanosine Monophosphate-Dependent Protein Kinase I in Renal Antifibrotic Effects of Serelaxin
por: Wetzl, Veronika, et al.
Publicado: (2016)

Inhibition of hypoxia-inducible factor 1α accumulation by glyceryl trinitrate and cyclic guanosine monophosphate
por: Kim, Judy, et al.
Publicado: (2020)

Cyclic Guanosine Monophosphate and Risk of Incident Heart Failure and Other Cardiovascular Events: the ARIC Study
por: Zhao, Di, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_4tfi3o75t5a6hc49if8qr2jfim