Cargando…

Dexamethasone prophylaxis protects from acute high-altitude illness by modifying the peripheral blood mononuclear cell inflammatory transcriptome

Acute high-altitude (HA) exposure can induce several pathologies. Dexamethasone (DEX) can be taken prophylactically to prevent HA disease, but the mechanism by which it acts in this setting is unclear. We studied the transcriptome of peripheral blood mononuclear cells (PBMCs) from 16 subjects at low...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kumar, Rahul, Chanana, Neha, Sharma, Kavita, Palmo, Tsering, Lee, Michael H., Mishra, Aastha, Nolan, Kevin, Fonseca Balladares, Dara C., Mickael, Claudia, Gupta, Mohit D., Thinlas, Tashi, Pasha, Qadar, Graham, Brian B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2023
Materias:	Cardiovascular System & Vascular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695741/ https://www.ncbi.nlm.nih.gov/pubmed/37975243 http://dx.doi.org/10.1042/BSR20231561

Ejemplares similares

Hypertensive Patients Exhibit Enhanced Thrombospondin-1 Levels at High-Altitude
por: Sharma, Kavita, et al.
Publicado: (2021)

The EDN1 Missense Variant rs5370G > T Regulates Adaptation and Maladaptation under Hypobaric Hypoxia
por: Palmo, Tsering, et al.
Publicado: (2022)

Disparities in COVID-19 incidence and fatality rates at high-altitude
por: Abbasi, Bilal Ahmed, et al.
Publicado: (2023)

Sexual Dimorphism of Dexamethasone as a Prophylactic Treatment in Pathologies Associated With Acute Hypobaric Hypoxia Exposure
por: Chanana, Neha, et al.
Publicado: (2022)

Vascular homeostasis at high-altitude: role of genetic variants and transcription factors
por: Chanana, Neha, et al.
Publicado: (2020)

Differential methylation in EGLN1 associates with blood oxygen saturation and plasma protein levels in high-altitude pulmonary edema
por: Sharma, Kavita, et al.
Publicado: (2022)

The Telomere-Telomerase System Is Detrimental to Health at High-Altitude
por: Pasha, Qadar, et al.
Publicado: (2023)

Interactions among Vascular-Tone Modulators Contribute to High Altitude Pulmonary Edema and Augmented Vasoreactivity in Highlanders
por: Ali, Zahara, et al.
Publicado: (2012)

Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension
por: Kumar, Rahul, et al.
Publicado: (2023)

Statin-induced microRNAome alterations modulating inflammation pathways of peripheral blood mononuclear cells in patients with hypercholesterolemia
por: Lin, Hung-Ju, et al.
Publicado: (2020)

ROCK2 and MYLK variants under hypobaric hypoxic environment of high altitude associate with high altitude pulmonary edema and adaptation
por: Pandey, Priyanka, et al.
Publicado: (2015)

Molecular Mechanisms of High-Altitude Acclimatization
por: Mallet, Robert T., et al.
Publicado: (2023)

Association of GNB3 C825T polymorphism with plasma electrolyte balance and susceptibility to hypertension
por: Nejatizadeh, Azim, et al.
Publicado: (2011)

Closed loop anaesthesia at high altitude (3505 m above sea level): Performance characteristics of an indigenously developed closed loop anaesthesia delivery system
por: Puri, Goverdhan D, et al.
Publicado: (2012)

A Study on the Molecular Mechanism of High Altitude Heart Disease in Children
por: Tashi, Qu-Zhen, et al.
Publicado: (2022)

Dexamethasone-loaded keratin films for ocular surface reconstruction
por: Schwab, Rebekka, et al.
Publicado: (2022)

Impact of endocrine disruptors on peripheral blood mononuclear cells in vitro: role of gender
por: Maddalon, Ambra, et al.
Publicado: (2023)

Elevated blood plasma levels of epinephrine, norepinephrine, tyrosine hydroxylase, TGFβ1, and TNFα associated with high-altitude pulmonary edema in an Indian population
por: Pandey, Priyanka, et al.
Publicado: (2016)

Right heart function during simulated altitude in patients with pulmonary arterial hypertension
por: Seccombe, Leigh M, et al.
Publicado: (2017)

Vitamin D deficiency promotes large rupture-prone abdominal aortic aneurysms and cholecalciferol supplementation limits progression of aneurysms in a mouse model
por: Nsengiyumva, Vianne, et al.
Publicado: (2020)

Tim-3 promotes tube formation and decreases tight junction formation in vascular endothelial cells
por: Cong, Yizi, et al.
Publicado: (2020)

Experimental evidence and network pharmacology-based analysis reveal the molecular mechanism of Tongxinluo capsule administered in coronary heart diseases
por: Li, Guode, et al.
Publicado: (2020)

Association between ALMS 1 variants and early-onset coronary artery disease: a case–control study in Chinese population
por: Zhang, Shao-Yan, et al.
Publicado: (2020)

Neuregulins: protective and reparative growth factors in multiple forms of cardiovascular disease
por: Geissler, Andrew, et al.
Publicado: (2020)

Involvement of amylin B-H(2)S-connexin 43 signaling pathway in vascular dysfunction and enhanced ischemia–reperfusion-induced myocardial injury in diabetic rats
por: Liu, Xiaoyong, et al.
Publicado: (2020)

Identification of feature autophagy-related genes in patients with acute myocardial infarction based on bioinformatics analyses
por: Du, Yajuan, et al.
Publicado: (2020)

Gene polymorphism associated with angiotensinogen (M235T), endothelial lipase (584C/T) and susceptibility to coronary artery disease: a meta-analysis
por: Zhao, Hongyan, et al.
Publicado: (2020)

MicroRNAs in ascending thoracic aortic aneurysms
por: Moushi, Areti, et al.
Publicado: (2020)

The coronary artery calcium score is linked to plasma cholesterol synthesis and absorption markers: Brazilian Longitudinal Study of Adult Health
por: Nunes, Valéria Sutti, et al.
Publicado: (2020)

miRNA-1183-targeted regulation of Bcl-2 contributes to the pathogenesis of rheumatic heart disease
por: Li, Ni, et al.
Publicado: (2020)

APLP2 gene polymorphisms are associated with high TC and LDL-C levels in Chinese population in Xinjiang, China
por: Abuzhalihan, Jialin, et al.
Publicado: (2020)

Comparison of a novel cholesterol efflux assay using immobilized liposome-bound gel beads with the conventional method
por: Horiuchi, Yuna, et al.
Publicado: (2020)

KAP1 silencing relieves OxLDL-induced vascular endothelial dysfunction by down-regulating LOX-1
por: Yan, Tianqing, et al.
Publicado: (2020)

Diabetic atherosclerosis: is there a role for the hypoxia-inducible factors?
por: Pirri, Daniela, et al.
Publicado: (2020)

Physiological cyclic stretch up-regulates angiotensin-converting enzyme 2 expression to reduce proliferation and migration of vascular smooth muscle cells
por: Song, Jiantao, et al.
Publicado: (2020)

The serum angiotensin-converting enzyme 2 and angiotensin-(1-7) concentrations after optimal therapy for acute decompensated heart failure with reduced ejection fraction
por: Hisatake, Shinji, et al.
Publicado: (2020)

MiR-377-3p inhibits atherosclerosis-associated vascular smooth muscle cell proliferation and migration via targeting neuropilin2
por: Wang, Haijun, et al.
Publicado: (2020)

Microvascular disease in chronic kidney disease: the base of the iceberg in cardiovascular comorbidity
por: Querfeld, Uwe, et al.
Publicado: (2020)

From animal models to patients: the role of placental microRNAs, miR-210, miR-126, and miR-148a/152 in preeclampsia
por: Frazier, Sonya, et al.
Publicado: (2020)

Sex-based differences in myocardial infarction-induced kidney damage following cigarette smoking exposure: more renal protection in premenopausal female mice
por: Habeichi, Nada J., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_3la1p7mk17bbpt7m31m1cmas4i