Carboxypeptidase A4 negatively regulates HGS-ETR1/2-induced pyroptosis by forming a positive feedback loop with the AKT signalling pathway

Pyroptosis, a mode of inflammatory cell death, has recently gained significant attention. However, the underlying mechanism remains poorly understood. HGS-ETR1/2 is a humanized monoclonal antibody that can bind to DR4/5 on the cell membrane and induce cell apoptosis by activating the death receptor...

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Detalles Bibliográficos
Autores principales: Wang, Luoling, Deng, Rilin, Chen, Shuishun, Tian, Renyun, Guo, Mengmeng, Chen, Zihao, Zhang, Yingdan, Li, Huiyi, Liu, Qian, Tang, Songqing, Zhu, Haizhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696061/
https://www.ncbi.nlm.nih.gov/pubmed/38049405
http://dx.doi.org/10.1038/s41419-023-06327-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696061/
https://www.ncbi.nlm.nih.gov/pubmed/38049405
http://dx.doi.org/10.1038/s41419-023-06327-5

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