PD-1 Impairs CD8(+) T Cell Granzyme B Production in Aged Mice during Acute Viral Respiratory Infection

CD8(+) T cell dysfunction contributes to severe respiratory viral infection outcomes in older adults. CD8(+) T cells are the primary cell type responsible for viral clearance. With increasing age, CD8(+) T cell function declines in conjunction with an accumulation of cytotoxic tissue-resident memory...

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Detalles Bibliográficos
Autores principales: Parks, Olivia B., Antos, Danielle, Eddens, Taylor, Walters, Sara, Johnson, Monika, Oury, Tim D., Gottschalk, Rachel A., Erickson, John J., Williams, John V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2023
Materias:
Adaptive Immunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696419/
https://www.ncbi.nlm.nih.gov/pubmed/38015461
http://dx.doi.org/10.4049/immunohorizons.2300094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696419/
https://www.ncbi.nlm.nih.gov/pubmed/38015461
http://dx.doi.org/10.4049/immunohorizons.2300094

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