Evidence of a Distinctive Enantioselective Binding Mode for the Photoinduced Radical Cyclization of α-Chloroamides in Ene-Reductases

[Image: see text] We demonstrate here through molecular simulations and mutational studies the origin of the enantioselectivity in the photoinduced radical cyclization of α-chloroacetamides catalyzed by ene-reductases, in particular the Gluconobacter oxidans ene-reductase and the Old Yellow Enzyme 1...

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Detalles Bibliográficos
Autores principales: Capone, Matteo, Dell’Orletta, Gianluca, Nicholls, Bryce T., Scholes, Gregory D., Hyster, Todd K., Aschi, Massimiliano, Daidone, Isabella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696551/
http://dx.doi.org/10.1021/acscatal.3c03934

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696551/
http://dx.doi.org/10.1021/acscatal.3c03934

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