Detection of oxaliplatin- and cisplatin-DNA lesions requires different global genome repair mechanisms that affect their clinical efficacy

The therapeutic efficacy of cisplatin and oxaliplatin depends on the balance between the DNA damage induction and the DNA damage response of tumor cells. Based on clinical evidence, oxaliplatin is administered to cisplatin-unresponsive cancers, but the underlying molecular causes for this tumor spec...

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Detalles Bibliográficos
Autores principales: Slyskova, Jana, Muniesa-Vargas, Alba, da Silva, Israel Tojal, Drummond, Rodrigo, Park, Jiyeong, Häckes, David, Poetsch, Isabella, Ribeiro-Silva, Cristina, Moretton, Amandine, Heffeter, Petra, Schärer, Orlando D, Vermeulen, Wim, Lans, Hannes, Loizou, Joanna I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
DNA Damage Sensing and Repair
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696645/
http://dx.doi.org/10.1093/narcan/zcad057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696645/
http://dx.doi.org/10.1093/narcan/zcad057

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