FGF-independent MEK1/2 signalling in the developing foetal testis is essential for male germline differentiation in mice

BACKGROUND: Disrupted germline differentiation or compromised testis development can lead to subfertility or infertility and are strongly associated with testis cancer in humans. In mice, SRY and SOX9 induce expression of Fgf9, which promotes Sertoli cell differentiation and testis development. FGF9...

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Detalles Bibliográficos
Autores principales: Blücher, Rheannon O., Lim, Rachel S., Jarred, Ellen G., Ritchie, Matthew E., Western, Patrick S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696798/
http://dx.doi.org/10.1186/s12915-023-01777-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696798/
http://dx.doi.org/10.1186/s12915-023-01777-x

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