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Whole-brain modeling of the differential influences of amyloid-beta and tau in Alzheimer’s disease

BACKGROUND: Alzheimer’s disease is a neurodegenerative condition associated with the accumulation of two misfolded proteins, amyloid-beta (A[Formula: see text] ) and tau. We study their effect on neuronal activity, with the aim of assessing their individual and combined impact. METHODS: We use a who...

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Detalles Bibliográficos
Autores principales: Patow, Gustavo, Stefanovski, Leon, Ritter, Petra, Deco, Gustavo, Kobeleva, Xenia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696890/
http://dx.doi.org/10.1186/s13195-023-01349-9