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Frequent, infinitesimal bottlenecks maximize the rate of microbial adaptation
Serial passaging is a fundamental technique in experimental evolution. The choice of bottleneck severity and frequency poses a dilemma: longer growth periods allow beneficial mutants to arise and grow over more generations, but simultaneously necessitate more severe bottlenecks with a higher risk of...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10697810/ https://www.ncbi.nlm.nih.gov/pubmed/37804525 http://dx.doi.org/10.1093/genetics/iyad185 |