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Frequent, infinitesimal bottlenecks maximize the rate of microbial adaptation
Serial passaging is a fundamental technique in experimental evolution. The choice of bottleneck severity and frequency poses a dilemma: longer growth periods allow beneficial mutants to arise and grow over more generations, but simultaneously necessitate more severe bottlenecks with a higher risk of...
Autores principales: | Delaney, Oscar, Letten, Andrew D, Engelstädter, Jan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10697810/ https://www.ncbi.nlm.nih.gov/pubmed/37804525 http://dx.doi.org/10.1093/genetics/iyad185 |
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