Mutational comparison of the single-domained APOBEC3C and double-domained APOBEC3F/G anti-retroviral cytidine deaminases provides insight into their DNA target site specificities

Human APOBEC3F and APOBEC3G are double-domained deaminases that can catalyze dC→dU deamination in HIV-1 and MLV retroviral DNA replication intermediates, targeting T–C or C–C dinucleotides, respectively. HIV-1 antagonizes their action through its vif gene product, which has been shown (at least in t...

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Detalles Bibliográficos
Autores principales: Langlois, Marc-André, Beale, Rupert C. L., Conticello, Silvestro G., Neuberger, Michael S.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1074398/
https://www.ncbi.nlm.nih.gov/pubmed/15809227
http://dx.doi.org/10.1093/nar/gki343

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1074398/
https://www.ncbi.nlm.nih.gov/pubmed/15809227
http://dx.doi.org/10.1093/nar/gki343

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