Site-specific incorporation of N-(deoxyguanosin-8-yl)-2-acetylaminofluorene (dG-AAF) into oligonucleotides using modified ‘ultra-mild’ DNA synthesis

Aromatic amino and nitro compounds are potent carcinogens found in the environment that exert their toxic effects by reacting with DNA following metabolic activation. One important adduct is N-(deoxyguanosin-8-yl)-2-acetylaminofluorene (dG-AAF), which has been extensively used in studies of the mech...

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Detalles Bibliográficos
Autores principales: Gillet, Ludovic C. J., Alzeer, Jawad, Schärer, Orlando D.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1074722/
https://www.ncbi.nlm.nih.gov/pubmed/15814813
http://dx.doi.org/10.1093/nar/gki335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1074722/
https://www.ncbi.nlm.nih.gov/pubmed/15814813
http://dx.doi.org/10.1093/nar/gki335

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