Cargando…
Pre-organized structure of viral DNA at the binding-processing site of HIV-1 integrase
The integration of the human immunodeficiency virus type 1 DNA into the host cell genome is catalysed by the viral integrase (IN). The reaction consists of a 3′-processing [dinucleotide released from each 3′ end of the viral long terminal repeat (LTR)] followed by a strand transfer (insertion of the...
Autores principales: | Renisio, Jean-Guillaume, Cosquer, Sylvain, Cherrak, Ilham, Antri, Saïd El, Mauffret, Olivier, Fermandjian, Serge |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2005
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1074723/ https://www.ncbi.nlm.nih.gov/pubmed/15814814 http://dx.doi.org/10.1093/nar/gki346 |
Ejemplares similares
-
An Unusual Helix Turn Helix Motif in the Catalytic Core of HIV-1 Integrase Binds Viral DNA and LEDGF
por: Merad, Hayate, et al.
Publicado: (2009) -
Specificity of LTR DNA recognition by a peptide mimicking the HIV-1 integrase α4 helix
por: Hobaika, Zeina, et al.
Publicado: (2009) -
The HIV-1 Integrase α4-Helix Involved in LTR-DNA Recognition Is also a Highly Antigenic Peptide Element
por: Azzi, Sandy, et al.
Publicado: (2010) -
Unprocessed Viral DNA Could Be the Primary Target of the HIV-1 Integrase Inhibitor Raltegravir
por: Ammar, Farah F., et al.
Publicado: (2012) -
Monoclonal antibodies that recognize important functional elements of the HIV-1 integrase enzyme
por: Maroun, Richard G, et al.
Publicado: (2012)