Repair activity of base and nucleotide excision repair enzymes for guanine lesions induced by nitrosative stress

Nitric oxide (NO) induces deamination of guanine, yielding xanthine and oxanine (Oxa). Furthermore, Oxa reacts with polyamines and DNA binding proteins to form cross-link adducts. Thus, it is of interest how these lesions are processed by DNA repair enzymes in view of the genotoxic mechanism of NO....

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Detalles Bibliográficos
Autores principales: Nakano, Toshiaki, Katafuchi, Atsushi, Shimizu, Ryoko, Terato, Hiroaki, Suzuki, Toshinori, Tauchi, Hiroshi, Makino, Keisuke, Skorvaga, Milan, Van Houten, Bennett, Ide, Hiroshi
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1079971/
https://www.ncbi.nlm.nih.gov/pubmed/15831791
http://dx.doi.org/10.1093/nar/gki513

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1079971/
https://www.ncbi.nlm.nih.gov/pubmed/15831791
http://dx.doi.org/10.1093/nar/gki513

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