Overexpression of Bcl-2 is associated with apoptotic resistance to the G-quadruplex ligand 12459 but is not sufficient to confer resistance to long-term senescence

The triazine derivative 12459 is a potent G-quadruplex interacting agent that inhibits telomerase activity. This agent induces time- and dose-dependent telomere shortening, senescence-like growth arrest and apoptosis in the human A549 tumour cell line. We show here that 12459 induces a delayed apopt...

Descripción completa

Detalles Bibliográficos
Autores principales: Douarre, Céline, Gomez, Dennis, Morjani, Hamid, Zahm, Jean-Marie, O'Donohue, Marie-Françoise, Eddabra, Lahcen, Mailliet, Patrick, Riou, Jean-François, Trentesaux, Chantal
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1079972/
https://www.ncbi.nlm.nih.gov/pubmed/15831792
http://dx.doi.org/10.1093/nar/gki514

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1079972/
https://www.ncbi.nlm.nih.gov/pubmed/15831792
http://dx.doi.org/10.1093/nar/gki514

Ejemplares similares