Characterization of the DNA-binding domain and identification of the active site residue in the ‘Gyr A’ half of Leishmania donovani topoisomerase II

DNA topoisomerase II is a multidomain homodimeric enzyme that changes DNA topology by coupling ATP hydrolysis to the transport of one DNA helix through a transient double-stranded break in another. To investigate the biochemical properties of the individual domains of Leishmania donovani topoisomera...

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Detalles Bibliográficos
Autores principales: Sengupta, Tanushri, Mukherjee, Mandira, Das, Rakhee, Das, Aditi, Majumder, Hemanta K.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087781/
https://www.ncbi.nlm.nih.gov/pubmed/15860773
http://dx.doi.org/10.1093/nar/gki527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087781/
https://www.ncbi.nlm.nih.gov/pubmed/15860773
http://dx.doi.org/10.1093/nar/gki527

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