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Sequence determinants of protein aggregation: tools to increase protein solubility

Escherichia coli is one of the most widely used hosts for the production of recombinant proteins. However, very often the target protein accumulates into insoluble aggregates in a misfolded and biologically inactive form. Bacterial inclusion bodies are major bottlenecks in protein production and are...

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Detalles Bibliográficos
Autor principal: Ventura, Salvador
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087874/
https://www.ncbi.nlm.nih.gov/pubmed/15847694
http://dx.doi.org/10.1186/1475-2859-4-11