How many clones need to be sequenced from a single forensic or ancient DNA sample in order to determine a reliable consensus sequence?

Forensic and ancient DNA (aDNA) extracts are mixtures of endogenous aDNA, existing in more or less damaged state, and contaminant DNA. To obtain the true aDNA sequence, it is not sufficient to generate a single direct sequence of the mixture, even where the authentic aDNA is the most abundant (e.g....

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Detalles Bibliográficos
Autores principales: Bower, Mim A., Spencer, Matthew, Matsumura, Shuichi, Nisbet, R. Ellen R., Howe, Christopher J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1088305/
https://www.ncbi.nlm.nih.gov/pubmed/15870386
http://dx.doi.org/10.1093/nar/gki550

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1088305/
https://www.ncbi.nlm.nih.gov/pubmed/15870386
http://dx.doi.org/10.1093/nar/gki550

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