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How many clones need to be sequenced from a single forensic or ancient DNA sample in order to determine a reliable consensus sequence?
Forensic and ancient DNA (aDNA) extracts are mixtures of endogenous aDNA, existing in more or less damaged state, and contaminant DNA. To obtain the true aDNA sequence, it is not sufficient to generate a single direct sequence of the mixture, even where the authentic aDNA is the most abundant (e.g....
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2005
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1088305/ https://www.ncbi.nlm.nih.gov/pubmed/15870386 http://dx.doi.org/10.1093/nar/gki550 |