Inhibition of double-strand break non-homologous end-joining by cisplatin adducts in human cell extracts

The effect of cis-diaminedichloroplatinum(II) (cisplatin) DNA damage on the repair of double-strand breaks by non-homologous end-joining (NHEJ) was determined using cell-free extracts. NHEJ was dramatically decreased when plasmid DNA was damaged to contain multiple types of DNA adducts, along the mo...

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Detalles Bibliográficos
Autores principales: Diggle, C. P., Bentley, J., Knowles, M. A., Kiltie, A. E.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1088968/
https://www.ncbi.nlm.nih.gov/pubmed/15872216
http://dx.doi.org/10.1093/nar/gki528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1088968/
https://www.ncbi.nlm.nih.gov/pubmed/15872216
http://dx.doi.org/10.1093/nar/gki528

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