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RAG1 Core and V(D)J Recombination Signal Sequences Were Derived from Transib Transposons

The V(D)J recombination reaction in jawed vertebrates is catalyzed by the RAG1 and RAG2 proteins, which are believed to have emerged approximately 500 million years ago from transposon-encoded proteins. Yet no transposase sequence similar to RAG1 or RAG2 has been found. Here we show that the approxi...

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Detalles Bibliográficos
Autores principales: Kapitonov, Vladimir V, Jurka, Jerzy
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1131882/
https://www.ncbi.nlm.nih.gov/pubmed/15898832
http://dx.doi.org/10.1371/journal.pbio.0030181