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A phase I study of hydralazine to demethylate and reactivate the expression of tumor suppressor genes
BACKGROUND: The antihypertensive compound hydralazine is a known demethylating agent. This phase I study evaluated the tolerability and its effects upon DNA methylation and gene reactivation in patients with untreated cervical cancer. METHODS: Hydralazine was administered to cohorts of 4 patients at...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1131894/ https://www.ncbi.nlm.nih.gov/pubmed/15862127 http://dx.doi.org/10.1186/1471-2407-5-44 |