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Schedule-selective biochemical modulation of 5-fluorouracil in advanced colorectal cancer – a phase II study

BACKGROUND: 5-fluorouracil remains the standard therapy for patients with advanced/metastatic colorectal cancer. Pre-clinical studies have demonstrated the biological modulation of 5-fluorouracil by methotrexate and leucovorin. This phase II study was initiated to determine the activity and toxicity...

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Detalles Bibliográficos
Autores principales: Tomlinson, Shannon K, Melin, Susan A, Higgs, Vetta, White, Douglas R, Savage, Paul, Case, Douglas, Blackstock, A William
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC113263/
https://www.ncbi.nlm.nih.gov/pubmed/11988109
http://dx.doi.org/10.1186/1471-2407-2-9