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Schedule-selective biochemical modulation of 5-fluorouracil in advanced colorectal cancer – a phase II study
BACKGROUND: 5-fluorouracil remains the standard therapy for patients with advanced/metastatic colorectal cancer. Pre-clinical studies have demonstrated the biological modulation of 5-fluorouracil by methotrexate and leucovorin. This phase II study was initiated to determine the activity and toxicity...
Autores principales: | Tomlinson, Shannon K, Melin, Susan A, Higgs, Vetta, White, Douglas R, Savage, Paul, Case, Douglas, Blackstock, A William |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2002
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC113263/ https://www.ncbi.nlm.nih.gov/pubmed/11988109 http://dx.doi.org/10.1186/1471-2407-2-9 |
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