5-Halogenated pyrimidine lesions within a CpG sequence context mimic 5-methylcytosine by enhancing the binding of the methyl-CpG-binding domain of methyl-CpG-binding protein 2 (MeCP2)

Perturbations in cytosine methylation signals are observed in the majority of human tumors; however, it is as yet unknown how methylation patterns become altered. Epigenetic changes can result in the activation of transforming genes as well as in the silencing of tumor suppressor genes. We report th...

Descripción completa

Detalles Bibliográficos
Autores principales: Valinluck, Victoria, Liu, Pingfang, Kang, Joseph I., Burdzy, Artur, Sowers, Lawrence C.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1140371/
https://www.ncbi.nlm.nih.gov/pubmed/15917437
http://dx.doi.org/10.1093/nar/gki612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1140371/
https://www.ncbi.nlm.nih.gov/pubmed/15917437
http://dx.doi.org/10.1093/nar/gki612

Ejemplares similares