5-Halogenated pyrimidine lesions within a CpG sequence context mimic 5-methylcytosine by enhancing the binding of the methyl-CpG-binding domain of methyl-CpG-binding protein 2 (MeCP2)

Perturbations in cytosine methylation signals are observed in the majority of human tumors; however, it is as yet unknown how methylation patterns become altered. Epigenetic changes can result in the activation of transforming genes as well as in the silencing of tumor suppressor genes. We report th...

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Detalles Bibliográficos
Autores principales: Valinluck, Victoria, Liu, Pingfang, Kang, Joseph I., Burdzy, Artur, Sowers, Lawrence C.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1140371/
https://www.ncbi.nlm.nih.gov/pubmed/15917437
http://dx.doi.org/10.1093/nar/gki612

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