A monoclonal antibody that inhibits mycobacterial DNA gyrase by a novel mechanism

DNA gyrase is a DNA topoisomerase indispensable for cellular functions in bacteria. We describe a novel, hitherto unknown, mechanism of specific inhibition of Mycobacterium smegmatis and Mycobacterium tuberculosis DNA gyrase by a monoclonal antibody (mAb). Binding of the mAb did not affect either Gy...

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Detalles Bibliográficos
Autores principales: Manjunatha, Ujjini H., Maxwell, Anthony, Nagaraja, Valakunja
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1142348/
https://www.ncbi.nlm.nih.gov/pubmed/15930158
http://dx.doi.org/10.1093/nar/gki622

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1142348/
https://www.ncbi.nlm.nih.gov/pubmed/15930158
http://dx.doi.org/10.1093/nar/gki622

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