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Mutational analysis of the PITX2 coding region revealed no common cause for transposition of the great arteries (dTGA)
BACKGROUND: PITX2 is a bicoid-related homeodomain transcription factor that plays an important role in asymmetric cardiogenesis. Loss of function experiments in mice cause severe heart malformations, including transposition of the great arteries (TGA). TGA accounts for 5–7% of all congenital heart d...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1142516/ https://www.ncbi.nlm.nih.gov/pubmed/15890066 http://dx.doi.org/10.1186/1471-2350-6-20 |