MSH2 missense mutations alter cisplatin cytotoxicity and promote cisplatin-induced genome instability

Defects in the mismatch repair protein MSH2 cause tolerance to DNA damage. We report how cancer-derived and polymorphic MSH2 missense mutations affect cisplatin cytotoxicity. The chemotolerance phenotype was compared with the mutator phenotype in a yeast model system. MSH2 missense mutations display...

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Detalles Bibliográficos
Autores principales: Clodfelter, Jill E., Gentry, Michael B., Drotschmann, Karin
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1148170/
https://www.ncbi.nlm.nih.gov/pubmed/15947132
http://dx.doi.org/10.1093/nar/gki646

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1148170/
https://www.ncbi.nlm.nih.gov/pubmed/15947132
http://dx.doi.org/10.1093/nar/gki646

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