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MSH2 missense mutations alter cisplatin cytotoxicity and promote cisplatin-induced genome instability
Defects in the mismatch repair protein MSH2 cause tolerance to DNA damage. We report how cancer-derived and polymorphic MSH2 missense mutations affect cisplatin cytotoxicity. The chemotolerance phenotype was compared with the mutator phenotype in a yeast model system. MSH2 missense mutations display...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2005
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1148170/ https://www.ncbi.nlm.nih.gov/pubmed/15947132 http://dx.doi.org/10.1093/nar/gki646 |