Estimating haplotype frequencies in pooled DNA samples when there is genotyping error

BACKGROUND: Maximum likelihood estimates of haplotype frequencies can be obtained from pooled DNA using the expectation maximization (EM) algorithm. Through simulation, we investigate the effect of genotyping error on the accuracy of haplotype frequency estimates obtained using this algorithm. We ex...

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Detalles Bibliográficos
Autores principales: Quade, Shannon RE, Elston, Robert C, Goddard, Katrina AB
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1156884/
https://www.ncbi.nlm.nih.gov/pubmed/15943883
http://dx.doi.org/10.1186/1471-2156-6-25

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1156884/
https://www.ncbi.nlm.nih.gov/pubmed/15943883
http://dx.doi.org/10.1186/1471-2156-6-25

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