The role of the Zn(II) binding domain in the mechanism of E. coli DNA topoisomerase I

BACKGROUND: Escherichia coli DNA topoisomerase I binds three Zn(II) with three tetracysteine motifs which, together with the 14 kDa C-terminal region, form a 30 kDa DNA binding domain (ZD domain). The 67 kDa N-terminal domain (Top67) has the active site tyrosine for DNA cleavage but cannot relax neg...

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Detalles Bibliográficos
Autores principales: Ahumada, Adriana, Tse-Dinh, Yuk-Ching
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC115839/
https://www.ncbi.nlm.nih.gov/pubmed/12052259
http://dx.doi.org/10.1186/1471-2091-3-13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC115839/
https://www.ncbi.nlm.nih.gov/pubmed/12052259
http://dx.doi.org/10.1186/1471-2091-3-13

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